A transcriptomic signature that predicts cancer recurrence after hepatectomy in patients with colorectal liver metastases.

ABSTRACT:

Background

Cancer recurrence is an important predictor of survival outcomes in patients with colorectal cancer-associated liver metastasis (CRLM), who undergo radical hepatectomy. Therefore, identification of patients with the greatest risk of recurrence is critical for developing a precision oncology strategy that might include frequent surveillance (in low-risk patients) or a more aggressive treatment approach (in high-risk patients). We performed genome-wide expression profiling, to identify and develop a transcriptomic signature for predicting recurrence in patients with CRLM.

Methods

We analysed a total of 383 patients with CRLM, including 63 patients from a publicly available data set (the NCBI's Gene Expression Omnibus with accession number GSE81423). and 320 patients

SUBMITTER: Wada Y 

PROVIDER: S-EPMC8860859 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature