Quantifying seizure termination patterns reveals limited pathways to seizure end.

ABSTRACT:

Objective

Despite their possible importance in the design of novel neuromodulatory approaches and in understanding status epilepticus, the dynamics and mechanisms of seizure termination are not well studied. We examined intracranial recordings from patients with epilepsy to differentiate seizure termination patterns and investigated whether these patterns are indicative of different underlying mechanisms.

Methods

Seizures were classified into one of two termination patterns: (a) those that end simultaneously across the brain (synchronous), and (b) those whose termination is piecemeal across the cortex (asynchronous). Both types ended with either a burst suppression pattern, or continuous seizure activity. These patterns were quantified and compared using burst suppression ra

SUBMITTER: Salami P 

PROVIDER: S-EPMC8860887 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature