Innate Immune Activation and Circulating Inflammatory Markers in Preschool Children.

ABSTRACT: Early childhood is characterised by repeated infectious exposures that result in inflammatory responses by the innate immune system. In addition, this inflammatory response to infection is thought to contribute to the epidemiological evidence linking childhood infection and adult non-communicable diseases. Consequently, the relationship between innate immune responses and inflammation during early life may inform prevention of NCDs later in life. In adults, non-genetic host factors such as age, sex, and obesity, strongly impact cytokine production and circulating mediators, but data in children are lacking. Here, we assessed cytokine responses and inflammatory markers in a population of healthy preschool children (mean age 4.2 years). We studied associations between cytokines, plasma infla

SUBMITTER: Collier F 

PROVIDER: S-EPMC8860896 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature