Diagnostic value of ¹⁸F-FDG PET-CT in detecting malignant peripheral nerve sheath tumors among adult and pediatric neurofibromatosis type 1 patients.

ABSTRACT:

Purpose

Detecting malignant peripheral nerve sheath tumors (MPNSTs) remains difficult. ¹⁸F-FDG PET-CT has been shown helpful, but ideal threshold values of semi-quantitative markers remain unclear, partially because of variation among scanners. Using EU-certified scanners diagnostic accuracy of ideal and commonly used ¹⁸F-FDG PET-CT thresholds were investigated and differences between adult and pediatric lesions were evaluated.

Methods

A retrospective cohort study was performed including patients from two hospitals with a clinical or radiological suspicion of MPNST between 2013 and 2019. Several markers were studied for ideal threshold values and differences among adults and children. A diagnostic algorithm was subsequently developed.

Results

Six

SUBMITTER: Geitenbeek RTJ 

PROVIDER: S-EPMC8860956 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature