Cadherin-11 Regulates Macrophage Development and Function.

ABSTRACT: Cadherin-11 (CDH11) is a cell-cell adhesion protein that has previously been reported to play an important role in the pathogenesis of pulmonary fibrosis. It is expressed on macrophages in the fibrotic lung. However, the role of CDH11 on macrophage biology has not yet been studied. We show using immunophenotypic analyses that Cdh11^-/- mice have fewer recruited monocyte-derived macrophages and Ly6C^hi monocytes in the lungs compared to wild-type mice in the intraperitoneal bleomycin-induced pulmonary fibrosis model. Additionally, fewer Ly6C^hi monocytes were detected in the bone marrow and peripheral blood of naive Cdh11^-/- mice. Given that macrophages are derived from monocytes, we investigated the precursors of the monocyte/macrophag

SUBMITTER: To S 

PROVIDER: S-EPMC8860974 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature