Universal relation for life-span energy consumption in living organisms: Insights for the origin of aging.

ABSTRACT: Metabolic energy consumption has long been thought to play a major role in the aging process (Pearl, The rate of living. University of London Press, London, 1928). Across species, a gram of tissue expends approximately the same amount of energy during the lifespan on average (Speakman, J Exp Biol 208:1717-1730, 2005). Energy restriction has also been shown to increase the maximum lifespan (McCay et al. J Nutr 10:63-79, 1935) and to retard age-associated changes (Weindruch and Walford, The retardation of aging and disease by dietary restriction. CC Thomas, Springfield, 1988). However, there are significant exceptions to universal energy consumption during the lifespan, mainly found by interclass comparison (Ramsey et al. Free Rad Biol Med 29:946-968, 2000; Atanasov, Trakia J Sci 10(3):1-14,

SUBMITTER: Escala A 

PROVIDER: S-EPMC8861023 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature