Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease.

ABSTRACT: Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc. contribute to the development of coronary atherosclerosis and subsequent coronary artery disease. Inflammation plays an important role in coronary artery disease development and progression. Pro-inflammatory signals promote the degradation of tryptophan via the kynurenine pathway resulting in the formation of several immunomodulatory metabolites. An unbalanced kynurenic pathway has been implicated in the pathomechanisms of various diseases including CAD. Significant improvements in detection methods in the last decades may allow simultaneous measurement of mu

SUBMITTER: Gaspar R 

PROVIDER: S-EPMC8861075 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature