Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation.

ABSTRACT:

Background

Interleukin-1 receptor antagonists can reduce mortality in septic shock patients with hepatobiliary dysfunction and disseminated intravascular coagulation (HBD + DIC), an organ failure pattern with inflammatory features consistent with macrophage activation. Identification of clinical phenotypes in sepsis may allow for improved care. We aim to describe the occurrence of HBD + DIC in a contemporary cohort of patients with sepsis and determine the association of this phenotype with known macrophage activation syndrome (MAS) biomarkers and mortality. We performed a retrospective nested case-control study in adult septic shock patients with concurrent HBD + DIC and an equal number of age-matched controls, with comparative analyses of all-cause mortality and circulating bioma

SUBMITTER: Anderko RR 

PROVIDER: S-EPMC8861227 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature