Prospective Association Between Inflammatory Markers and Knee Cartilage Volume Loss and Pain Trajectory.

ABSTRACT:

Introduction

Inflammation has been suggested to be involved in the pathogenesis of osteoarthritis and pain. We sought to explore the associations between inflammatory serum markers and magnetic resonance imaging-defined long-term structural change and pain trajectory.

Methods

A total of 169 randomly selected participants (mean age 63 years; 47% female) from a prospective cohort study were included in this study. Circulating levels of interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-α) and high-sensitivity C-reactive protein (CRP) were measured at baseline. A knee MRI scan was performed to measure cartilage volume (CV) and bone marrow lesions (BMLs) at baseline and at 10.7 years. Knee pain at four visits was measured by the WOMAC pain questionnaire, and pain trajectori

SUBMITTER: Pan F 

PROVIDER: S-EPMC8861228 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature