Treatment Transitions in Chronic Obstructive Pulmonary Disease: Retrospective Analyses of US and UK Healthcare Databases.

ABSTRACT:

Introduction

Previous studies have reported that more patients receive inhaled corticosteroid (ICS)-containing therapies than would be expected based on exacerbation history, suggesting overprescribing. We aimed to describe patterns of treatment switching from first (1MT) to second maintenance therapy (2MT) among COPD patients in the US and UK.

Methods

We used healthcare data from the US IBM^® MarketScan^® and UK Clinical Practice Research Datalink databases (2015 - 2018) to assess transitions between 1MT and 2MT among COPD patients. Patients with a recorded asthma diagnosis prior to 1MT were excluded. We assessed whether prescribed treatments (long-acting muscarinic antagonists [LAMA], long-acting β₂-agonists [LABA], inhaled corticosteroids [I

SUBMITTER: Bloom CI 

PROVIDER: S-EPMC8861248 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature