Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure.

ABSTRACT:

Aims

A diet with modified components, such as a ketogenic low-carbohydrate (LC) diet, potentially extends longevity and healthspan. However, how an LC diet impacts on cardiac pathology during haemodynamic stress remains elusive. This study evaluated the effects of an LC diet high in either fat (Fat-LC) or protein (Pro-LC) in a mouse model of chronic hypertensive cardiac remodelling.

Methods and results

Wild-type mice were subjected to transverse aortic constriction, followed by feeding with the Fat-LC, the Pro-LC, or a high-carbohydrate control diet. After 4 weeks, echocardiographic, haemodynamic, histological, and biochemical analyses were performed. LC diet consumption after pressure overload inhibited the development of pathological hypertrophy and systolic dysfunction co

SUBMITTER: Nakamura M 

PROVIDER: S-EPMC8861266 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature