Dissociable impairments of verbal learning differentiate childhood risk profiles for schizophrenia.

ABSTRACT: Poor verbal learning and memory function is well-documented among individuals with schizophrenia and those at clinical high-risk for psychosis. This study aimed to identify these impairments among children aged 9-12 years with different schizophrenia risk profiles (family history or antecedents of schizophrenia, each of higher^[H] or lower^[L] risk load) relative to typically developing peers. These three groups were recruited via community-screening, and differentiated for analysis into: typically developing children (TD = 45); children who had 1 first- or ≥2 second-degree affected relatives (FHx^H = 16) or one second-degree relative (FHx^L = 15); and children presenting multiple replicated antecedents of schizophrenia whose clinical symptoms persis

SUBMITTER: Carpendale EJ 

PROVIDER: S-EPMC8861403 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature