Intrinsic network connectivity reflects the cyclic trajectory of migraine attacks.

ABSTRACT:

Background

Episodic migraine is considered to be cyclic in nature, triggered by the hypothalamus. To assess the natural trajectory of intrinsic networks over an entire migraine cycle, we designed a longitudinal intra-individual study using functional magnetic resonance imaging (fMRI).

Methods

Intrinsic network connectivity was assessed for 12 migraineurs in 82 sessions including spontaneous, untriggered headache attacks and follow-up recordings towards the next attack.

Results

We found cyclic changes in the visual, auditory, and somatosensory networks, in limbic networks (e.g. thalamo-insular, parahippocampal), and in the salience network (anterior insula and dorsal anterior cingulate cortex). Connectivity changes also extended to further cortical networks, such as th

SUBMITTER: Stankewitz A 

PROVIDER: S-EPMC8861450 | biostudies-literature | 2022 Jan-Jul

REPOSITORIES: biostudies-literature