Effects of 1,25-Dihydroxyvitamin D₃ and 25-Hydroxyvitamin D₃ on PBMCs From Dairy Cattle Naturally Infected With Mycobacterium avium subsp. paratuberculosis.

ABSTRACT: The role of vitamin D₃ in modulating immune responses has been well-established for over two decades; however, its specific functions have not been extensively detailed in cattle, particularly cattle in different stages of infection with Mycobacterium avium subspecies paratuberculosis (MAP). Consistent with previous work in our lab, the present study showed that infected cattle in the clinical stage of disease have reduced serum 25-hydroxyvitamin D₃ [25(OH)D₃]. Additionally, effects of vitamin D₃ on peripheral blood mononuclear cells (PBMCs) from naturally infected dairy cattle in subclinical (n = 8) or clinical (n = 8) stages of infection were compared to non-infected control cows (n = 8). Briefly, PBMCs were i

SUBMITTER: Wherry TLT 

PROVIDER: S-EPMC8861496 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature