Gut Mucosal Microbiome Signatures of Colorectal Cancer Differ According to BMI Status.

ABSTRACT:

Background

Carrying excess body weight is a strong risk factor for colorectal cancer (CRC) development with ~11% of CRC cases in Europe linked to being overweight. The mechanisms through which excess body weight influences CRC development are not well understood but studies suggest the involvement of the presence of chronic low-grade inflammation and changes in the gut microbiota are involved.

Aim

To compare the mucosal associated microbiota of patients with CRC to understand whether carrying excess body weight was associated with a unique CRC microbial signature.

Methods

Microbiota signatures from colonic mucosal biopsies of CRC lesions and adjacent normal mucosal samples from 20 patients with overt CRC were compared with 11 healthy controls to see if having a BMI of

SUBMITTER: Shaw S 

PROVIDER: S-EPMC8861504 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature