Pre-existing maternal IgG antibodies as a protective factor against congenital cytomegalovirus infection: A mother-child prospective cohort study.

ABSTRACT:

Background

An understanding of the correlation between maternal immunity and congenital cytomegalovirus (CMV) infection is critical for informing the design and evaluation of an effective maternal vaccine. This study aimed to quantitatively measure the protective effect of pre-existing maternal immunity against congenital CMV (cCMV) infection.

Methods

A mother-child cohort study was conducted in three maternal and child health hospitals in China from 2015 to 2018. Pregnant women were consecutively enrolled, and anti-CMV pp150 IgG concentration at early, middle and late gestational ages were evaluated. Their newborns were screened for cCMV infection by CMV-DNA testing of saliva and urine.

Findings

In total, 6729 pregnant women were enrolled, and 6602 of them (98·11%) w

SUBMITTER: Huang Y 

PROVIDER: S-EPMC8861648 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature