Ontology highlight
ABSTRACT:
SUBMITTER: Andrea AE
PROVIDER: S-EPMC8861853 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Frontiers in immunology 20220208
During this last decade, adoptive transfer of T lymphocytes genetically modified to express chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in hematological cancers. However, this immunotherapy has demonstrated limited efficacy in solid tumors. The main obstacle encountered by CAR-T cells in solid malignancies is the immunosuppressive tumor microenvironment (TME). The TME impedes tumor trafficking and penetration of T lymphocytes and installs an immunosuppressive mil ...[more]