Endothelial Cells Promote Productive HIV Infection of Resting CD4⁺ T Cells by an Integrin-Mediated Cell Adhesion-Dependent Mechanism.

ABSTRACT: Resting CD4⁺ T cells are primary targets of early HIV infection events in vivo, but do not readily support HIV replication in vitro. This barrier to infection can be overcome by exposing resting CD4⁺ T cells to endothelial cells (ECs). ECs line blood vessels and direct T cell trafficking into inflamed tissues. Cell trafficking pathways have been shown to have overlapping roles in facilitating HIV replication, but their relevance to EC-mediated enhancement of HIV susceptibility in resting CD4⁺ T cells has not previously been examined. We characterized the phenotype of primary human resting CD4⁺ T cells that became productively infected with HIV when cocultured with primary human blood and lymphatic ECs. The infected CD4⁺ T

SUBMITTER: Card CM 

PROVIDER: S-EPMC8861939 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature