Long-Term Effects of Sevelamer on Vascular Calcification, Arterial Stiffness, and Calcification Propensity in Patients Receiving Peritoneal Dialysis: The Randomized Pilot SERENE (Sevelamer on Vascular Calcification, Arterial Stiffness) Trial.

ABSTRACT:

Rationale & objective

There is a concern regarding increased risk of vascular calcification with the use of calcium-based phosphorus binders. This study aimed to compare the effects of sevelamer used as a second-line, low-dose therapy with calcium-based phosphorus binders with those of sevelamer used as a first-line, high-dose therapy on coronary artery and heart valve calcification, aortic pulse wave velocity (PWV), and calcification propensity over 2 years in patients with hyperphosphatemia receiving peritoneal dialysis (PD).

Study design

A 2-year-long prospective, multicenter, open-label, randomized pilot study.

Setting & participants

Prevalent patients with hyperphosphatemia receiving PD from 2 university-affiliated hospitals in Hong Kong.

Interventions

The

SUBMITTER: Wang AY 

PROVIDER: S-EPMC8861951 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature