A unique circulating miRNA profile highlights thrombo-inflammation in Behcet's syndrome.

ABSTRACT:

Objectives

Behçet's syndrome (BS) is a rare systemic vasculitis often complicated by thrombotic events. Given the lack of validated biomarkers, BS diagnosis relies on clinical criteria.In search of novel biomarkers for BS diagnosis, we determined the profile of plasmatic circulating microRNAs (ci-miRNAs) in patients with BS compared with healthy controls (HCs).

Methods

ci-miRNA profile was evaluated by microarray in a screening cohort (16 patients with BS and 18 HCs) and then validated by poly(T) adaptor PCR (PTA-PCR) in a validation cohort (30 patients with BS and 30 HCs). Two disease control groups (30 patients with systemic lupus erythematosus (SLE) and 30 patients with giant cell arteritis (GCA) were also analysed.

Results

From the microarray screening, 29 deregul

SUBMITTER: Emmi G 

PROVIDER: S-EPMC8862064 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature