Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice.

ABSTRACT:

Objective

To investigate the abundance and the prevalence of Dysosmobacter welbionis J115^T, a novel butyrate-producing bacterium isolated from the human gut both in the general population and in subjects with metabolic syndrome. To study the impact of this bacterium on host metabolism using diet-induced obese and diabetic mice.

Design

We analysed the presence and abundance of the bacterium in 11 984 subjects using four human cohorts (ie, Human Microbiome Project, American Gut Project, Flemish Gut Flora Project and Microbes4U). Then, we tested the effects of daily oral gavages with live D. welbionis J115^T on metabolism and several hallmarks of obesity, diabetes, inflammation and lipid metabolism in obese/diabetic mice.

Results

This n

SUBMITTER: Le Roy T 

PROVIDER: S-EPMC8862106 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature