CAR directs T cell adaptation to bile acids in the small intestine.

ABSTRACT: Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine¹. As detergents, bile acids can cause toxicity and inflammation in enterohepatic tissues². Nuclear receptors maintain bile acid homeostasis in hepatocytes and enterocytes³, but it is unclear how mucosal immune cells tolerate high concentrations of bile acids in the small intestine lamina propria (siLP). CD4⁺ T effector (T_eff) cells upregulate expression of the xenobiotic transporter MDR1 (encoded by Abcb1a) in the siLP to prevent bile acid toxicity and suppress Crohn's disease-like small bowel inflammation⁴. Here we identify the nuclear xenobiotic receptor CAR

SUBMITTER: Chen ML 

PROVIDER: S-EPMC8862117 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature