Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Gottingen minipigs.

ABSTRACT:

Background

Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients. Xenotransplantation holds great promise to overcome the shortage of human donor organs after solving the problems of rejection, functionality and virus safety. We recently described the transmission of a human-tropic recombinant PERV-A/C, designated PERV-F, from peripheral blood mononuclear cells (PBMCs) of a Göttingen Minipig (GöMP) to human 293 cells (Krüger et al., in Viruses 12(1):38, 2019). The goal of this study was to characterize PERV-F in more detail and to analyze the probability of virus isolation from other animals.

Methods

The recombination site in the envelope (env) gene, the lo

SUBMITTER: Halecker S 

PROVIDER: S-EPMC8862210 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature