Genetic regulation of the ompX porin of Salmonella Typhimurium in response to hydrogen peroxide stress.

ABSTRACT:

Background

Salmonella Typhimurium is a Gram-negative pathogen that causes a systemic disease in mice resembling typhoid fever. During its infective cycle, S. Typhimurium is phagocytized by macrophages and proliferates inside a Salmonella-containing vacuole where Salmonella is exposed and survives oxidative stress induced by H₂O₂ through modulation of gene expression. After exposure of Salmonella to H₂O₂, the expression of the porin-encoding gene ompX increases, as previously shown by microarray analysis. Expression of ompX mRNA is regulated at a post-transcriptional level by MicA and CyaR sRNAs in aerobiosis. In addition, sequence analysis predicts a site for OxyS sRNA in ompX mRNA.

Results

In this work we sought to evaluate the tr

SUBMITTER: Briones AC 

PROVIDER: S-EPMC8862304 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature