Genomic characterization of the world's longest selection experiment in mouse reveals the complexity of polygenic traits.

ABSTRACT:

Background

Long-term selection experiments are a powerful tool to understand the genetic background of complex traits. The longest of such experiments has been conducted in the Research Institute for Farm Animal Biology (FBN), generating extreme mouse lines with increased fertility, body mass, protein mass and endurance. For >140 generations, these lines have been maintained alongside an unselected control line, representing a valuable resource for understanding the genetic basis of polygenic traits. However, their history and genomes have not been reported in a comprehensive manner yet. Therefore, the aim of this study is to provide a summary of the breeding history and phenotypic traits of these lines along with their genomic characteristics. We further attempt to decipher the ef

SUBMITTER: Palma-Vera SE 

PROVIDER: S-EPMC8862358 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature