Insulin use in chronic kidney disease and the risk of hypoglycemic events.

ABSTRACT:

Background

We examined in persons with type 2 diabetes (T2D) whether the use of insulin and the risk of serious hypoglycemic events with insulin is higher in persons with more advanced CKD.

Methods

In a national cohort of 855,133 veterans with T2D seen at Veteran Affairs clinics between Jan 1, 2008 and December 31, 2010 with at least two serum creatinine measurements, we defined insulin use from pharmacy records and serious hypoglycemic events by ICD-9/10 codes from emergency room visits or hospitalizations that occurred until December 31, 2016.

Results

Mean age was 66 ± 11 years and 97% were men. Mean baseline eGFR was 73 ± 22 ml/min/1.73 m². In a multivariable Cox regression model of those without insulin use at baseline (N = 653,200), compared to eGFR ≥9

SUBMITTER: Grube D 

PROVIDER: S-EPMC8862360 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature