Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

ABSTRACT:

Objective

Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cerebrospinal (CSF) tau, p-tau-181p, or Aβ levels after non-cardiac, non-neurologic surgery in older adults.

Methods

Participants underwent cognitive testing before and 6 weeks after surgery, and lumbar punctures before, 24 h after, and 6 weeks after surgery. Cognitive scores were combined via factor analysis into an overall cognitive index. In total, 110 patients returned for 6-week postoperative testing and were included in the analysis.

Results

There was no significant change from before to 24 h or 6 weeks following sur

SUBMITTER: Berger M 

PROVIDER: S-EPMC8862419 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature