STWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy.

ABSTRACT:

Objective

Leukoaraiosis (LA) refers to white matter lesions of undetermined etiology associated with the appearance and worsening of vascular pathologies. The aim is to confirm an increased frequency and intensity of LA in symptomatic patients with neurovascular pathology compared with asymptomatic subjects, and its association with circulating serum levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK).

Methods

An observational study was conducted in which two groups of patients were compared. Group I (N = 242) comprised of asymptomatic subjects with arterial hypertension and/or diabetes or with a history of transient ischemic attacks, and Group II (N = 382) comprised patients with lacunar stroke or deep hemispheric intracerebral hemorrhage (ICH) o

SUBMITTER: da Silva-Candal A 

PROVIDER: S-EPMC8862435 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature