Comparative efficacy and safety of oral anticoagulants for the treatment of venous thromboembolism in the patients with different renal functions: a systematic review, pairwise and network meta-analysis.

ABSTRACT:

Objectives

To compare the efficacy and safety of direct oral anticoagulants (DOACs) in patients with venous thromboembolism (VTE) and different renal functions.

Design

Systematic review containing pairwise and Bayesian network meta-analysis of randomised controlled trials (RCTs).

Data sources

MEDLINE, EMBASE and Cochrane Library.

Eligibility criteria

RCTs reporting the efficacy and safety outcomes of DOACs in different creatinine clearance (CrCl) subgroups.

Data extraction and synthesis

Data extraction and quality assessment were undertaken by two independent reviewers. Data were pooled using the DerSimonian-Laird method in pairwise meta-analysis. Network meta-analysis within a Bayesian framework was conducted.

Results

Data from 10 RCTs were inclu

SUBMITTER: Su X 

PROVIDER: S-EPMC8862458 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature