Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock.

ABSTRACT:

Background

A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples. Whether discordant tick rates between tissue-specific and general epigenetic clocks play a role in health and disease has not yet been explored.

Results

Here we analyze 1941 cervical cytology samples, which contain a mixture of hormone-sensitive cervical epithelial cells and immune cells, and develop the WID general clock (Women's IDentification of risk), an epigenetic clock that is shared by epithelial and immune cells and optimized for cervical samples. We then develop the WID epithelial clock and WID immune clock, which define epithelial- and immune-specific cl

SUBMITTER: Barrett JE 

PROVIDER: S-EPMC8862470 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature