Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis.

ABSTRACT:

Background

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone disease for which a lack of bacterial involvement is a key diagnostic feature to distinguish it from other symptomatically related diseases. However, the growing evidence suggesting an involvement of the host-associated microbiota in rheumatic disorders together with the now wide accessibility of modern culture-independent methods warrant a closer examination of CRMO.

Methods

In this study, we show through bacterial 16S rRNA gene profiling that numerous features of the oral- and fecal microbial communities differentiate children with and without CRMO.

Results

Notably, communities in diseased children are characterized by a lack of potential probiotic bacteria in the fecal comm

SUBMITTER: Rausch P 

PROVIDER: S-EPMC8862485 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature