A novel qualitative signature based on lncRNA pairs for prognosis prediction in hepatocellular carcinoma.

ABSTRACT:

Background

Prognostic assessment is imperative for clinical management of patients with hepatocellular carcinoma (HCC). Most reported prognostic signatures are based on risk scores summarized from quantitative expression level of candidate genes, which are vulnerable against experimental batch effects and impractical for clinical application. We aimed to develop a robust qualitative signature to assess individual survival risk for HCC patients.

Methods

Long non-coding RNA (lncRNA) pairs correlated with overall survival (OS) were identified and an optimal combination of lncRNA pairs based on the majority voting rule was selected as a classification signature to predict the overall survival risk in the cancer genome atlas (TCGA). Then, the signature was further validated in tw

SUBMITTER: Bu X 

PROVIDER: S-EPMC8862507 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature