The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel.

ABSTRACT:

Background

Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex traits while controlling for confounding environmental factors is often problematic. To address this, we establish a vertebrate genetic resource specifically to allow for robust genotype-to-phenotype investigations. The teleost medaka (Oryzias latipes) is an established genetic model system with a long history of genetic research and a high tolerance to inbreeding from the wild.

Results

Here we present the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel: the first near-isogenic panel of 80 inbred lines in a vertebrate model derived from a wild founder population. Inbred lines provide fixed genomes that are a prereq

SUBMITTER: Fitzgerald T 

PROVIDER: S-EPMC8862526 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature