Paired Feed-Forward Excitation With Delayed Inhibition Allows High Frequency Computations Across Brain Regions.

ABSTRACT: The transmission of high frequency temporal information across brain regions is critical to perception, but the mechanisms underlying such transmission remain unclear. Long-range projection patterns across brain areas are often comprised of paired feed-forward excitation followed closely by delayed inhibition, including the thalamic triad synapse, thalamic projections to cortex, and projections within the hippocampus. Previous studies have shown that these joint projections produce a shortened period of depolarization, sharpening the timing window over which the postsynaptic neuron can fire. Here we show that these projections can facilitate the transmission of high frequency computations even at frequencies that are highly filtered by neuronal membranes. This temporal facilitation occurre

SUBMITTER: Cao AS 

PROVIDER: S-EPMC8862685 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature