Duodenal microbiome changes in postmenopausal women: effects of hormone therapy and implications for cardiovascular risk.

ABSTRACT:

Objective

Hormone therapy (HT) is used to treat menopause-related conditions and symptoms. The small intestine plays key roles in metabolic and endocrine function, but the effects of HT on the small intestinal microbiome are unknown. Here, we characterize duodenal microbiome differences, and the effects of HT, in postmenopausal women.

Methods

Female participants undergoing esophagogastroduodenoscopy who were postmenopausal and taking HT (HT+), postmenopausal but not taking HT (HT-), or of reproductive age and not taking exogenous hormones (RA), were identified and matched for body mass index (±3 kg/m2). DNAs were isolated from duodenal aspirates obtained during upper endoscopy. V3 and V4 libraries were used for 16S rRNA sequencing. Serum hormone levels were analyzed by Lumin

SUBMITTER: Leite G 

PROVIDER: S-EPMC8862775 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature