Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats.

ABSTRACT:

Background and purpose

Diabetic nephropathy is a common complications related to high morbidity and mortality in type 2 diabetes. We investigated the action of the dual modulator, PTUPB, a soluble epoxide hydrolase and cyclooxygenase-2 inhibitor against diabetic nephropathy.

Experimental approach

Sixteen-week-old type 2 diabetic and proteinuric obese ZSF1 rats were treated with vehicle, PTUPB or enalapril for 8 weeks. Measurements were made of epoxyeicosatrienoic acids, thromboxane B₂ (TBX₂ ) and prostaglandin E2 (PGE₂ ) in the kidney of these and lean ZSF1 rats along with their blood pressure.

Key result

Obese ZSF1 rats were diabetic with fivefold higher fasting blood glucose levels and markedly higher HbA1c levels compared with lean

SUBMITTER: Khan MAH 

PROVIDER: S-EPMC8863090 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature