Evolution of the Quorum Sensing Regulon in Cooperating Populations of Pseudomonas aeruginosa.

ABSTRACT: In the opportunistic pathogenic bacterium Pseudomonas aeruginosa acyl-homoserine lactone quorum sensing (QS) can activate expression of dozens to hundreds of genes depending on the strain under investigation. Many QS-activated genes code for extracellular products. P. aeruginosa has become a model for studies of cell-cell communication and coordination of cooperative activities, which result from production of extracellular products. We hypothesized that strain variation in the size of the QS regulon might reflect the environmental history of an isolate. We tested the hypothesis by performing long-term growth experiments with the well-studied strain PAO1, which has a relatively large QS regulon, under conditions where only limited QS-controlled functions are required. We grew P. aeruginosa

SUBMITTER: Smalley NE 

PROVIDER: S-EPMC8863103 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature