A DNA replication-independent function of pre-replication complex genes during cell invasion in C. elegans.

ABSTRACT: Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. A screen of C. elegans orthologs of genes overexpressed in invasive human melanoma cells has identified several components of the conserved DNA pre-replication complex (pre-RC) as positive regulators of anchor cell (AC) invasion. The pre-RC genes function cell-autonomously in the G1-arrested AC to promote invasion, independently of their role in licensing DNA replication origins in proliferating cells. While the helicase activity of the pre-RC is necessary for AC invasion, the downstream acting DNA replication initiation factors are not required. The pre-RC promotes the invasive fate by regulating the expression of extracellular matrix genes and components of the PI3K signaling pa

SUBMITTER: Lattmann E 

PROVIDER: S-EPMC8863262 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature