Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis.

ABSTRACT: Angioblasts that form the major axial blood vessels of the dorsal aorta and cardinal vein migrate toward the embryonic midline from distant lateral positions. Little is known about what controls the precise timing of angioblast migration and their final destination at the midline. Using zebrafish, we found that midline angioblast migration requires neighboring tissue rearrangements generated by somite morphogenesis. The somitic shape changes cause the adjacent notochord to separate from the underlying endoderm, creating a ventral midline cavity that provides a physical space for the angioblasts to migrate into. The anterior to posterior progression of midline angioblast migration is facilitated by retinoic acid-induced anterior to posterior somite maturation and the subsequent progressive

SUBMITTER: Paulissen E 

PROVIDER: S-EPMC8863375 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature