Combination Therapy with GABA and MgSO₄ Improves Insulin Sensitivity in Type 2 Diabetic Rat.

ABSTRACT:

Background

Gamma-aminobutyric acid (GABA) and magnesium sulfate (MgSO₄) play a crucial role in glycemic control. Therefore, we studied the effect of combination therapy with GABA and MgSO₄ to improve insulin sensitivity in diabetes induced by streptozotocin as well as high-fat diet in a diabetic rat model. Design and Methods. Forty randomly selected rats were assigned to four groups: nondiabetic control group was fed the normal diet, insulin-resistant diabetic rat model was induced by streptozotocin and high-fat diet, GABA + MgSO₄ group received GABA and MgSO₄, and insulin group was treated with insulin. Body weight, abdominal fat, blood glucose, serum insulin, and glucagon concentration were measured. The glucose clamp technique,

SUBMITTER: Sohrabipour S 

PROVIDER: S-EPMC8863457 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature