29 m⁶A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation - 102 Transcriptomic Dataset Analyses.

ABSTRACT: We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m⁶A-RNA methylation (epitranscriptomic) regulators (m⁶A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m⁶A-RMRs were upregulated; and most m⁶A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m⁶A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m⁶A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m⁶A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m⁶A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m

SUBMITTER: Liu M 

PROVIDER: S-EPMC8863469 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature