Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.

ABSTRACT:

Objectives

Multiple organ failure in critically ill patients is associated with poor prognosis, but biomarkers contributory to pathogenesis are unknown. Previous studies support a role for Fas cell surface death receptor (Fas)-mediated apoptosis in organ dysfunction. Our objectives were to test for associations between soluble Fas and multiple organ failure, identify protein quantitative trait loci, and determine associations between genetic variants and multiple organ failure.

Design

Retrospective observational cohort study.

Setting

Four academic ICUs at U.S. hospitals.

Patients

Genetic analyses were completed in a discovery (n = 1,589) and validation set (n = 863). Fas gene expression and flow cytometry studies were completed in outpatient research participan

SUBMITTER: Mikacenic C 

PROVIDER: S-EPMC8863632 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature