Anticholinergic medication burden and cognitive function in participants of the ASPREE study.

ABSTRACT:

Study objective

What is the association between anticholinergic burden and specific domains of cognitive function in older adults who are initially without major cognitive impairment?

Design

Post-hoc analysis of longitudinal observational data from the ASPirin in Reducing Events in the Elderly (ASPREE) study.

Patients

19,114 participants from Australia and the United States aged 70 years and older (65 years and older for US minorities) were recruited and followed for a median of 4.7 years. At enrollment, participants were free of known cardiovascular disease, major physical disability, or dementia.

Measurements

Cognitive assessments administered at baseline and biennially at follow-up visits included the Modified Mini-Mental State examination (3MS), Hopkins Ver

SUBMITTER: Broder JC 

PROVIDER: S-EPMC8863638 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature