Differential Gene Sets Profiling in Gram-Negative and Gram-Positive Sepsis.

ABSTRACT:

Background

The host response to bacterial sepsis is reported to be nonspecific regardless of the causative pathogen. However, newer paradigms indicated that the host response of Gram-negative sepsis may be different from Gram-positive sepsis, and the difference has not been clearly clarified. The current study aimed to explore the difference by identifying the differential gene sets using the genome-wide technique.

Methods

The training dataset GSE6535 and the validation dataset GSE13015 were used for bioinformatics analysis. The distinct gene sets of sepsis with different infections were screened using gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA). The intersection gene sets based on the two algorithms were confirmed through Venn analysis. Finall

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8863667 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature