Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis.

ABSTRACT: Primary sclerosing cholangitis (PSC) is an idiopathic and heterogenous cholestatic liver disease characterized by chronic inflammation and fibrosis of the biliary tree. Currently, no effective therapies are available for this condition, whose incidence is rising. At present, specificity and sensitivity of current serum markers used to diagnose PSC are limited and often unreliable. In this study, we characterize circulating extracellular vesicles and provide supporting data on their potential use as novel surrogate biomarkers for PSC. EVs are membrane surrounded structures, 100-1000 nm in size, released by cells under various conditions and which carry a variety of bioactive molecules, including small non-coding RNAs, lipids and proteins. In recent years, a large body of evidence has pointe

SUBMITTER: Povero D 

PROVIDER: S-EPMC8863778 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature