Multimodal investigation of the association between shift work and the brain in a population-based sample of older adults.

ABSTRACT: Neuropsychological studies reported that shift workers show reduced cognitive performance and circadian dysfunctions which may impact structural and functional brain networks. Here we tested the hypothesis whether night shift work is associated with resting-state functional connectivity (RSFC), cortical thickness and gray matter volume in participants of the 1000BRAINS study for whom information on night shift work and imaging data were available. 13 PRESENT and 89 FORMER night shift workers as well as 430 control participants who had never worked in shift (NEVER) met these criteria and were included in our study. No associations between night shift work, three graph-theoretical measures of RSFC of 7 functional brain networks and brain morphology were found after multiple comparison correc

SUBMITTER: Bittner N 

PROVIDER: S-EPMC8863881 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature