A synthetic protein as efficient multitarget regulator against complement over-activation.

ABSTRACT: The complement system constitutes the innate defense against pathogens. Its dysregulation leads to diseases and is a critical determinant in many viral infections, e.g., COVID-19. Factor H (FH) is the main regulator of the alternative pathway of complement activation and could be a therapy to restore homeostasis. However, recombinant FH is not available. Engineered FH versions may be alternative therapeutics. Here, we designed a synthetic protein, MFHR13, as a multitarget complement regulator. It combines the dimerization and C5-regulatory domains of human FH-related protein 1 (FHR1) with the C3-regulatory and cell surface recognition domains of human FH, including SCR 13. In summary, the fusion protein MFHR13 comprises SCRs FHR1_1-2:FH_1-4:FH₁₃:FH_19-20<

SUBMITTER: Ruiz-Molina N 

PROVIDER: S-EPMC8863895 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature