Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.

ABSTRACT: Macromolecular proton fraction (MPF) is a quantitative MRI parameter describing the magnetization transfer (MT) effect and defined as a relative amount of protons bound to biological macromolecules with restricted molecular motion, which participate in magnetic cross-relaxation with water protons. MPF attracted significant interest during past decade as a biomarker of myelin. The purpose of this mini review is to provide a brief but comprehensive summary of MPF mapping methods, histological validation studies, and MPF applications in neuroscience. Technically, MPF maps can be obtained using a variety of quantitative MT methods. Some of them enable clinically reasonable scan time and resolution. Recent studies demonstrated the feasibility of MPF mapping using standard clinical MRI pulse seq

SUBMITTER: Kisel AA 

PROVIDER: S-EPMC8863973 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature