Functions of RNF Family in the Tumor Microenvironment and Drugs Prediction in Grade II/III Gliomas.

ABSTRACT: Increasing evidence has demonstrated that RING finger (RNF) proteins played a vital role in cellular and physiological processes and various diseases. However, the function of RNF proteins in low-grade glioma (LGG) remains unknown. In this study, 138 RNF family members revealed their role in LGG. The TCGA database was used as the training cohort; two CGGA databases and GSE108474 were selected as external validation cohorts. Patients were grouped into cluster 1 and cluster 2, both in the training and validation cohorts, using consensus clustering analysis. The prognosis of patients in cluster 1 is significantly better than that in cluster 2. Meanwhile, biofunction prediction was further introduced to explore the potential mechanisms that led to differences in survival outcomes. Patients in

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8864229 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature