Variant Rs556621 on Chromosome 6p21.1 and the Risk of Ischemic Stroke in Chinese Populations: A Meta-Analysis.

ABSTRACT: There are inconsistencies in the published findings on the association of variant rs556621 in an intergenic region on Chromosome 6p21.1 with the risk of developing ischemic stroke (IS) and a major IS subtype (large artery atherosclerosis, LAA) in Chinese populations. We conducted a meta-analysis to evaluate the association of variant rs556621 with IS/LAA risk using ten studies involving 3644 IS cases and 3692 controls (including seven studies involving 2268 LAA cases and 2268 controls) from China. The AA genotype increased IS risk (AA versus CC: odds ratio [OR] 1.19, 95% confidence interval [CI] 1.03-1.36, P = 0.015; AA versus CA + CC: OR 1.23, 95% CI 1.09-1.39, P = 0.001). Subgroup analysis also suggested that rs556621 contributed to the risk of IS both in Chinese Han and th

SUBMITTER: Chen L 

PROVIDER: S-EPMC8864279 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature